Reprogrammable Soft Swimmers for Minimally Invasive Thrombus Extraction

Авторы: Пожиткова A.В.Кладько Д., Винник Д.А., Таскаев С.В., Виноградов В.В.

ACS Appl. Mater. Interfaces, 2022, DOI: 10.1021/acsami.2c04745


Thrombosis-related diseases are the primary death cause in the world. Despite recent advances in thrombosis treatment methods, their invasive nature remains a crucial factor, which leads to considerable deadly consequences. Soft magnetic robots are attracting widespread interest due to their fast response, remote actuation, and shape reprogrammability and could potentially avoid the side effects of conventional approaches. This paper outlines a new approach to the thrombosis treatment via reprogrammable magnetic soft robots that penetrate, hook and extract the plasma clots in a vein-mimicking system under the applied rotating magnetic fields. We present the shape-switching bioinspired soft swimmers, capable of locomotion by different mechanisms in vein-mimicking flow conditions and which swimming efficiency is similar to animals. Further, we demonstrate the potential of a developed robot for minimally invasive thromboextraction with and without fibrinolytic usage, including hooking the plasma clot for 3.1±1.1 min and extracting it from the vein-mimicking system under applied magnetic fields. We consider interesting solution for thrombosis treatment to avoid substantial drawbacks of the existing methods.

DOI: 10.1021/acsami.2c04745

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