Authors: Kuchur О.А., Daria Kuzmina , Dukhinova M.S., Shtil A. A.
In response to therapeutic ionizing radiation, survival mechanisms are activated in tumor cells, which reduces the effectiveness of treatment. In the development of radioresistance, the key role is played by p53, p63, and p73, which constitute a family of proteins that regulate numerous pathways of intracellular signal transmission. Thus, by analyzing the expression of the tumor suppressor p53, it was possible to predict the absorbed dose at which a particular tumor response develops. However, information on the use of p63 and p73 in radiooncology is currently limited by experimental data and hypotheses about practical use. This work is filling the gap that has arisen, since the analysis of the p53 family as a whole gives a more detailed - and more complex - picture of the regulation of the response to radiation and identifies targets that are promising for use in radiation therapy.In response to therapeutic ionizing radiation, survival mechanisms are activated in tumor cells, which reduces the effectiveness of treatment. In the development of radioresistance, the key role is played by p53, p63, and p73, which constitute a family of proteins that regulate numerous pathways of intracellular signal transmission. Thus, by analyzing the expression of the tumor suppressor p53, it was possible to predict the absorbed dose at which a particular tumor response develops. However, information on the use of p63 and p73 in radiooncology is currently limited by experimental data and hypotheses about practical use. This work is filling the gap that has arisen, since the analysis of the p53 family as a whole gives a more detailed - and more complex - picture of the regulation of the response to radiation and identifies targets that are promising for use in radiation therapy.
doi: 10.32607/actanaturae.11247