Preparation and physicochemical properties of Nicotinamide@AlOOH biocompatible composite based on sol-gel materials

Authors: Vinogradov V.V., Komova Ya.M., Vinogradov A.V., Vinogradov V.V.


This paper is devoted to studying the properties of the functional nanocomposite nicotinamide@boehmite. Nicotinamide is introduced directly into a sol of boehmite with the subsequent aging and drying. The results of obtaining high-purity boehmite sol prepared with the use of ultrasonic machining as a physical method of peptization are presented. The structure of the composite is studied with the help of a complex of methods: X-ray-phase analysis, IR-spectroscopy, electron microscopy, and the low-temperature adsorption-desorption of nitrogen. The release of nicotinamide is studied in a histidine buffer at pH = 7.4. Forty-eight percent of the introduced nicotinamide is released in the first 2 h with subsequent sharp retardation resulting in a complete release for a long time.

DOI: 10.1134/S1995078014010157

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