Bifunctional RNA‐Targeting Deoxyribozyme Nanodevice as a Potential Theranostic Agent

Авторы: Спелков А.А.Гончарова Е.А., Савин А.М., Колпащиков Д.М.


Theranostic approaches rely on simultaneous diagnostic of a disease and its therapy. Here, we designed a DNA nanodevice, which can simultaneously report the presence of a specific RNA target through an increase in fluorescence and cleave it. High selectivity of RNA target recognition under near physiological conditions was achieved. The proposed approach can become a basis for the design of DNA nanomachines and robots for diagnostics and therapy of viral infections, cancer, and genetic disorders.

Keywords: DNA; RNA recognition; binary probes; deoxyribozymes; fluorescence; theranostics.


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