Bifunctional RNA‐Targeting Deoxyribozyme Nanodevice as a Potential Theranostic Agent

Authors: Spelkov A.A.Goncharova E.A., Savin A.M., Kolpashchikov D.M.

Abstract

Theranostic approaches rely on simultaneous diagnostic of a disease and its therapy. Here, we designed a DNA nanodevice, which can simultaneously report the presence of a specific RNA target through an increase in fluorescence and cleave it. High selectivity of RNA target recognition under near physiological conditions was achieved. The proposed approach can become a basis for the design of DNA nanomachines and robots for diagnostics and therapy of viral infections, cancer, and genetic disorders.

Keywords: DNA; RNA recognition; binary probes; deoxyribozymes; fluorescence; theranostics.

DOI10.1002/chem.201905528.

Read fullhttps://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.201905528.